Normal range: Negative
Comment: Antibodies against ganglioside are found in various types of peripheral neuropathy. These include Guillain-Barrie’ syndrome, Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy). Also seen in Motor neuron disease and chronic inflammatory demyelinating polyneuropathy
:Test profile
:The following antibodies are examined
GM1 : Monosialoganglioside GM1
GM2 : Monosialoganglioside GM2
GM3 : Monosialoganglioside GM3
GD1a : Disialoganglioside GD1a
GD1b : Disialoganglioside GD1b
GT1b : Trisialoganglioside GT1b
GQ1b : Tetrasialoganglioside GQ1b
Clinical significance: Motor neuron disease associated with GM1, up to 70% of cases. Guillain-Barrie‘ syndrome associated with GM1 in up to 30% of cases, and with less frequency to GM3, GD1a, GD1b, GT1b and GQ1b. Sensory neuropathy associated with GD1b. Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy) associated with GQ1b in 90% of the cases
Sample: serum