(Anti Gangliosides Ab (G/M

By | يونيو 5, 2014

Normal range: Negative

Comment: Antibodies against ganglioside are found in various types of peripheral neuropathy. These include Guillain-Barrie’ syndrome, Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy). Also seen in Motor neuron disease and chronic inflammatory demyelinating polyneuropathy

 

:Test profile

:The following antibodies are examined

GM1      : Monosialoganglioside GM1

GM2      : Monosialoganglioside GM2

GM3      : Monosialoganglioside GM3

GD1a    : Disialoganglioside GD1a

GD1b    : Disialoganglioside GD1b

GT1b     : Trisialoganglioside GT1b

GQ1b    : Tetrasialoganglioside GQ1b

 

Clinical significance: Motor neuron disease associated with GM1, up to 70% of cases. Guillain-Barrie‘ syndrome associated with GM1 in up to 30% of cases, and with less frequency to GM3, GD1a, GD1b, GT1b and GQ1b. Sensory neuropathy associated with GD1b. Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy) associated with GQ1b in 90% of the cases

Sample: serum