Alkaline phosphatase isoenzyme

By | يونيو 5, 2014

:Normal range

Total alkaline phosphatase: up to 290 u/l

Liver fraction: up to160 u/l

Bone fraction: up to 150

Intestine fraction: up to 5 u/l

Comment: Alkaline phosphatase is released into the circulation from a variety of tissue primarily liver, bone, intestine and placenta. Each has varying properties of heat stability

-1

Bone isoenzymes is increased in osteoblastic activity (& growth), and decreased in osteopenia due to genetic hypophatasemia, cretin hypothyroidism, chronic nutritional deficiency, vitamin B12 deficiency and pernicious anemia

-2

Liver isoenzyme (Fraction I) is increased in hepatic congestion, Vasculitis, pregnancy, and (Fraction II) in parenchymal cell damage

-3

Intestinal isoenzyme is increased in intestinal disease and in some individuals with blood type “O” or “B”, and particularly after meals

-4

Placental fraction appears in maternal serum in 3rd trimester

-5

Regan isoenzymes frequently detected in neoplastic disease

Sample: Serum