:Normal range
:Therapeutic Range
Peak level: 20-30 mg/L*
Trough level: < 5 mg/L*
Comment: Amikacin is used to treat serious infections caused by susceptible aerobic gram –negative bacilli for e.g., a number of the Enterobacteriaceae and P. aeruginosa. Amikacin is cleared by the kidney and accumulates in renal tubular cells. Nephrotoxicity is most closely related to the length of time that trough levels are greater than 8 mg/L. Creatinine levels should be monitored every 2-3 days as an indicator of impending renal toxicity. The initial toxic result is non-oliguric renal failure, which is usually reversible if the drug is discontinued. Continued administration of amikacin may produce oliguric renal failure. Nephrotoxicity may occur in as many as 10% to 25% of patients receiving aminoglycosides; most of this toxicity can be avoided by monitoring levels and adjusting dosing schedules accordingly
Sample: Serum