Anti-ganglioside antibodies

By | يونيو 11, 2014

:Introduction

Antibodies against ganglioside are found in various types of peripheral neuropathy. These include Guillain-Barrie’ syndrome, Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy). Also seen in Motor neuron disease and chronic inflammatory demyelinating polyneuropathy

:Test profile

:The following antibodies are examined

GM1  : Monosialoganglioside GM1

GM2  : Monosialoganglioside GM2

GM3  : Monosialoganglioside GM3

GD1a: Disialoganglioside GD1a

GD1b: Disialoganglioside GD1b

GT1b: Trisialoganglioside GT1b

GQ1b: Tetrasialoganglioside GQ1b

 

:Clinical significance

-1

Motor neuron disease associated with GM1, up to 70% of cases

-2

Guillain-Barrie’ syndrome associated with GM1 in up to 30% of cases, and with less frequency to GM3, GD1a, GD1b, GT1b and GQ1b

-3

Sensory neuropathy associated with GD1b

-4

Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy) associated with GQ1b in 90% of the cases

Material required: Serum*

 

We, in the First Medical Laboratory, are dedicated to bring the best of laboratory medicine to clinical practice to Jordan

Dr. Hussam Abu-Farsakh

American Board of Anatomic & Clinical Pathology, and Cytopathology

 

“Circular” is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature