ANTIBODIES IN NEUROLOGICAL DISEASE; DIAGNOSTIC SIGNIFICANCE

By | يونيو 11, 2014

Auto-antibody against neurological organs are associated with different diseases. Their recognition is essential in their diagnosis

:Anti-Hu, Anti-Ri,Anti-Yo

Para-neoplastic syndrome: Neurological disorders secondary to malignancy can manifest in patients long time before their malignancy is discovered. Patients can manifest with Cerebellar ataxia, encephalomyelitis , myoclonus, or sensory neuropathy. Detection of neuronal antibody : Anti-Yo (antibody against Cerebellar Purkinje cells) , Anti-Hu, Anti-Ri (against neuron nuclei ) are strongly associated with this syndrome

:Anti-GAD

Stiff man syndrome: is a syndrome of diffuse hypertonia of the muscles due to loss of inhibitory spinal interneurons associated with anti-GAD antibodies (Glutamic Acid decarboxylase). GAD are receptors in the cerebellum and other neurological organs

Amyotrophic lateral sclerosis can also be associated with anti-GAD

Cerebellar degeneration outside the context of para-neoplastic syndrome is associated with anti-GAD

:Anti-Myelin Antibody

Multiple sclerosis: Antibodies against myelin: can be associated with multiple sclerosis

:Anti-MAG

(Guillain Barre syndrome : is associated with myelin-associated glycoprotein (anti-MAG

These tests are performed at the First Medical Laboratory from serum of affected patients

 

We, in the First Medical Laboratory, are dedicated to bring the best of laboratory medicine to clinical practice to Jordan

Dr. Hussam Abu-Farsakh

American Board of Anatomic & Clinical Pathology, and Cytopathology

 

Circular: is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature