Apo E, Lipid Disorders and Coronary Artery Disease

By | يونيو 11, 2014

Introduction: Apo E mediates removal of chylomicron and VLDL remnants from plasma by binding these particles to LDL. Three different alleles are present for Apo E E2, E3, E4

Types of Apo E and clinical significance: ApoE3/E3 are present in about 77% of the total population and is the normal variant. Apo E3 is fully functioning and is associated with decreased plasma cholesterol levels. In contrast, Apo-E4 is present in 10-15% of the population, associated with increased cholesterol level and development of premature atherosclerosis. This genotype is associated with coronary artery disease. ApoE-4 still had an increased risk of heart disease, even if the patient�s cholesterol level and blood pressure were normal. Apo E-4 is associated strongly with Alzheimer�s disease, with patients having both alleles have an earlier onset than patients with one

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allele. One the other hand, Apo E2/E2 genotype is associated with familial dysbetalipoproteinemia (Type III hyperlipidemia ) with increased plasma cholesterol and Triglycerides. It is associated with accelerated arteriosclerosis , coronary heart disease and peripheral vascular disease

:(Indication for apo E genotype testing (either one

-1

Total serum cholesterol>240 mg/dl and Triglycerides >150 mg/dl

-2

(LDL cholesterol > (age of the patient + 100) and TG > (Age of the patient +100

-3

VLDL revealed by lipoprotein electrophoresis as broad beta band

Conclusion : Apo-E polymorphism is a major determinant of risk for the development of atherosclerotic vascular disease and coronary artery disease

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Dr. Hussam Abu-Farsakh

American Board of Anatomic & Clinical Pathology, and Cytopathology

Circular: is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature