Introduction: Cytogenetics of leukemia is extremely important today for the best diagnosis, treatment and prognosis of leukemia patients
:Examples
:(Acute Lymphoblastic Leukemia (ALL
(Prognosis is best in Hyperdiploid, then t(12;21), then t(1;19-
Patients who have t(12,21) respond very well to chemotherapy-
Patients with t(1,19) have poor prognosis and require bone marrow transplant-
(Adult ALL : Never demonstrate t(12,21) or t(1;19) but many are t(9;22
:(In Acute Myeloid Leukemia (AML
t(8,21) frequent translocation in M2 in adults and carry good prognosis, respond to Ara-C-
Inv 16 (P13;q 22); t(16;16) (usually in M4Eo) responds to Ara-C-
Patients with t(15,17) (seen in M3) respond to regimen ATRA/DNA-
All these genetic markers now govern the treatment modalities of leukemia cases
All these test can now be performed efficiently now in our lab
We, in the First Medical Laboratory, are determined to bring the best of laboratory medicine in clinical practice to Jordan
Please do not hesitate to contact me for further inquires
Dr. Hussam Abu-Farsakh
American boards of Anatomic, Clinical Pathology and Cytopathology