Breast carcinoma, lung carcinoma and thyroid carcinoma are one of the most common sources of unknown primary. Now with new immunohistochemistry, we can be sure of lung carcinoma origin by doing TTF-1 and by breast carcinoma origin by doing Gross Fluid cystic protein on the tumor tissue. Both markers are, for practical purposes, specific and sensitive for lung and breast carcinoma respectively., even for poorly differentiated carcinoma
Good example of this is detecting carcinoma in cervical or in axillary lymph nodes where the differential usually lies between breast and lung carcinoma, even with negative mammogram and negative chest X ray
“Thyroid Transcription Factor” detect thyroid carcinomas in metastatic sites
(Mesothelin” detect mesothelioma (where primary lung carcinoma is in the differential”
Detecting tumors of breast, lung, mesothelial or thyroid origin has different implications in therapy and prognosis
We, in the First Medical Laboratory, are determined to bring the best of laboratory medicine in clinical practice to Jordan
Please do not hesitate to contact me for further inquires
Dr. Hussam Abu-Farsakh
American boards of Anatomic, Clinical Pathology and Cytopathology
Circular: is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature