Introduction: A glycoprotein present in the surface membrane. This protein is important in the differential diagnosis of small blue cell tumors (large cell lymphoma, Neuroblastoma, Ewing’s sarcoma, Rhabdomyosarcoma and Primitive Neuroectodermal Tumor (PNET). Since the treatment of Ewing’s sarcoma, Extraskeletal Ewing’s sarcoma and Primitive Neuroectodermal Tumor depends very much in accurate diagnosis
:Clinical use
This test is very important in the diagnosis of Ewing’s sarcoma, Extraskeletal Ewing’s sarcoma, Primitive Neuroectodermal Tumor PNET
O13 is the only Immunohistochemical stain that is definite for Ewing’s sarcoma/ Primitive Neuroectodermal Tumor
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.Dr. Hussam Abu-Farsakh, M.D