Performing the complete profile of antibodies against nuclear antigens is very helpful is the diagnosis of different types of connective tissue diseases that are present. The full spectrum of
these antigens are as follows
nRNP, Sm, SS-A, SS-B, Scl-70, Jo-1, centromere, dsDNA, Histones, ribosomal P protein
Antibodies against these antigens can indicate specific disease pattern as shown below
Systemic lupus erythematosus: Anti-Double stranded DNA , Anti-Sm, anti-ribosomal P protein, anti-SS-A (RO), Anti-SS-B (La), Antihistone
(Sjogren’s syndrome: Anti-SS-A (Ro), Anti-SS-B(La
Mixed connective tissue disease: Anti-RNP
Scleroderma: Anti-Scl-70, Anti-PM-Scl, Anti-Ku
CREST: anticentromere
(Polymyositis: Anti-Jo1 (usually associated with interstitial lung fibrosis
Medication induced lupus: anti-histones
Material required: Serum
We, in the First Medical Laboratory, are dedicated to bring the best of laboratory medicine to clinical practice to Jordan
Dr. Hussam Abu-Farsakh
American Board of Anatomic & Clinical Pathology, and Cytopathology
Circular: is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature