Introduction: Apo E mediates removal of chylomicron and VLDL remnants from plasma by binding these particles to LDL. Three different alleles are present for Apo E E2, E3, E4
Types of Apo E and clinical significance: ApoE3/E3 are present in about 77% of the total population and is the normal variant. Apo E3 is fully functioning and is associated with decreased plasma cholesterol levels. In contrast, Apo-E4 is present in 10-15% of the population, associated with increased cholesterol level and development of premature atherosclerosis. This genotype is associated with coronary artery disease. ApoE-4 still had an increased risk of heart disease, even if the patient�s cholesterol level and blood pressure were normal. Apo E-4 is associated strongly with Alzheimer�s disease, with patients having both alleles have an earlier onset than patients with one
allele. One the other hand, Apo E2/E2 genotype is associated with familial dysbetalipoproteinemia (Type III hyperlipidemia ) with increased plasma cholesterol and Triglycerides. It is associated with accelerated arteriosclerosis , coronary heart disease and peripheral vascular disease
:(Indication for apo E genotype testing (either one
-1
Total serum cholesterol>240 mg/dl and Triglycerides >150 mg/dl
-2
(LDL cholesterol > (age of the patient + 100) and TG > (Age of the patient +100
-3
VLDL revealed by lipoprotein electrophoresis as broad beta band
Conclusion : Apo-E polymorphism is a major determinant of risk for the development of atherosclerotic vascular disease and coronary artery disease
We in the First Medical Lab are dedicated to bring the best of Laboratory medicine to clinical practice in Jordan
Dr. Hussam Abu-Farsakh
American Board of Anatomic & Clinical Pathology, and Cytopathology
Circular: is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature