Normal range: Negative
Comment: With new development in immunology, medical scientists discovered new tests fairly specific for Crohn’s disease and / or ulcerative colitis. These tests can also differentiate between Crohn’s disease and ulcerative colitis
– Antibodies against Saccharomyces cervisiae: They are frequently found in serum of patients with Crohn’s disease. IgA level, specific marker for Crohn’s disease, detectable in 63% of the cases (compared to 4% of ulcerative colitis patients, and 2% in normal population), Combined IgA and IgG detect 73% of the cases
– Antibodies against exocrine pancreases: is very specific marker for Crohn’s disease 39% of the cases, while is 0 % in ulcerative colitis and 0% in healthy controls
– Antibodies against intestinal goblet cells: This antibody is pathognomonic for ulcerative colitis IgA: in 28% of cases, IgG in 69% of the cases
p-ANCA: occur in ulcerative colitis in 66%, and in Crohn’s disease in 85%
The panel of 4 antibodies can detect altogether up to 90% of the cases of Crohn’s or ulcerative colitis. All these antibodies are important for follow up of the cases
Sample: serum