> 14 yrs
Comment: Results are elevated in sarcoidosis, more often when the disease is active and are of value in assessing the response of sarcoidosis to corticosteroid therapy.
A marked decreased is found in some patients on prednisone. A falling ACE level had been considered a favorable prognostic sign. Rising levels were thought to reflect activity uncontrolled by therapy, but its prognostic value in identification of subjects with progressive disease is limited. It also is used in investigation for Gaucher disease and maybe useful for monitoring noncompliance with ACE inhibitor treatment. ACE is thought to be produced by epithelioid cells and macrophages; elevations are found in a variety of Granulomatous disease