:Introduction
Antibodies against ganglioside are found in various types of peripheral neuropathy. These include Guillain-Barrie’ syndrome, Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy). Also seen in Motor neuron disease and chronic inflammatory demyelinating polyneuropathy
:Test profile
:The following antibodies are examined
GM1 : Monosialoganglioside GM1
GM2 : Monosialoganglioside GM2
GM3 : Monosialoganglioside GM3
GD1a: Disialoganglioside GD1a
GD1b: Disialoganglioside GD1b
GT1b: Trisialoganglioside GT1b
GQ1b: Tetrasialoganglioside GQ1b
:Clinical significance
-1
Motor neuron disease associated with GM1, up to 70% of cases
-2
Guillain-Barrie’ syndrome associated with GM1 in up to 30% of cases, and with less frequency to GM3, GD1a, GD1b, GT1b and GQ1b
-3
Sensory neuropathy associated with GD1b
-4
Miller Fisher syndrome (a variant of Guillain-Barrie’ with descending neuropathy) associated with GQ1b in 90% of the cases
Material required: Serum*
We, in the First Medical Laboratory, are dedicated to bring the best of laboratory medicine to clinical practice to Jordan
Dr. Hussam Abu-Farsakh
American Board of Anatomic & Clinical Pathology, and Cytopathology
“Circular” is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature