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:Normal range

IgG1: 65 %, IgG2: 25 %, IgG3: 6%, IgG4: 4%

(IgG Subclass levels (mg/dL

IgG4 IgG3 IgG2 IgG1 Age
6-63 9-62 30-140 190-620 0-1 y
4-43 11-98 30-170 230-710 1-2 y
3-120 6-130 40-240 280-830 2-3 y
5-180 9-160 50-310 350-810 3-6 y
11-620 13-320 30-630 270-1740 > 6 y

Comment: Approximately 80% of total serum immunoglobulin (Ig) in adults is IgG, which is divided into four subclasses on the basis of structural differences in the hinge region. IgG1 and IgG3 are closely related, as are IgG2 and IgG4. impaired synthesis or abnormal loss may cause deficiencies of one or more immunoglobulin subclasses. Selective IgG subclass deficiencies can occur in spite of a normal total IgG level. Study of patients with recurrent bacterial

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infections. Selective deficiencies maybe found among the subclasses in some individuals who suffer repeated infections, especially IgG1

Sample: serum