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Microvillous inclusion disease (MID) : Familial Microvillous Atrophy is a cause of intractable diarrhea in infancy. The light microscopy picture is usually normal and that may account for many cases that may passed unnoticed. Its diagnosis is used to be troublesome in the past. Usually the patient may have more than one time biopsy due to the requirement of Electron Microscopy for definitive diagnosis. Now, with new development in molecular pathology, Immunostaining for CD 10 is replacing electron microscopy for its definite diagnosis. CD10 is an enkephalinase which plays a role in final stages of peptide hydrolysis at the membrane surface. With the use of Immunostaining for CD 10, the absorptive cells stains strongly for CD 10 involving more than � of the surface enterocytes cytoplasm. This is due to accumulation of enkephalinase in the surface enterocytes

Simple duodenal biopsy submitted in formalin (instead of gluteraldehyde) is a good specimen for the definite diagnosis. The staining in this disease is pathognomonic for this disorder. Electron microscopy used to be the goal standard for this diagnosis. Now, CD 10 Immunostaining is substituting electron microscopy

 

We, in the First Medical Laboratory, are dedicated to bring the best of laboratory medicine to clinical practice to Jordan

Dr. Hussam Abu-Farsakh

American Board of Anatomic & Clinical Pathology, and Cytopathology