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ANCA (Anti-Neutrophilic Cytoplasmic Antigen) is very important test for vasculitis and inflammatory bowel diseases and certain hepatic lesions. It is important in the differential diagnosis of “Lung diseases” , “hematuria and/or proteinuria”, “abdominal pain and bloody diarrhea” and in “Cholestatic liver diseases”

(ANCA has 2 different patterns: Perinuclear ANCA (P-ANCA) and Cytoplasmic ANCA (C-ANCA

 C-ANCA is present more commonly in the following diseases: Wegener’s granulomatosis, Microscopic polyarteritis, Churg-Strauss syndrome

 P-ANCA is present in more wide variety of diseases: polyarteritis nodosa, idiopathic cresentic glomerunephritis, SLE, Rheumatoid Arthritis, Ulcerative Colitis, Crohn’s Disease, Primary Scleroing Cholangitis, Autoimmune Hepatitis, Primary Biliary Cirrhosis

Both tests are performed in our lab by immunofluorescence techniques


We, in the First Medical Laboratory, are dedicated to bring the best of laboratory medicine to clinical practice to Jordan

.Dr. Hussam Abu- Farsakh, M.D

American boards of Anatomic, Clinical Pathology and Cytopathology