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Normal range: Negative

Comment: This autoimmune antibody creates a strongly positive reaction in systemic lupus erythematous (SLE). Less positive reactions are found in other collagen vascular diseases, e.g. scleroderma, rheumatoid arthritis, polymyositis and systemic sclerosis. However, weakly positive reactions (e.g. 1/40) are not uncommon and are usually of little clinical significance. Imunofluorescence patterns correlate with type of disease

Sample: serum