Detecting CMV in tissue sections
Cytomegalovirus infection (CMV) is fairly common in Immunocompromised patients. Typical CMV inclusions detect only 20% of the cases and can miss up to 80% of the cases Now , we can perform CMV immunohistochemistry on any tissue suspected of CMV infections lung biopsy, Bronchial lavage, Esophageal biopsy, colonic biopsy, kidney biopsy, lymph node biopsy, blood […]
Detecting source of carcinoma of unknown primary
Breast carcinoma, lung carcinoma and thyroid carcinoma are one of the most common sources of unknown primary. Now with new immunohistochemistry, we can be sure of lung carcinoma origin by doing TTF-1 and by breast carcinoma origin by doing Gross Fluid cystic protein on the tumor tissue. Both markers are, for practical purposes, specific and […]
Diabetes Mellitus (DM) Type I and Autoantibodies
Making a diagnosis of Type I DM is of paramount importance as early as possible to start on correct treatment. Some patients may not present with classical symptoms of ketoacidosis. In fact some may be adult with overweight with maintained residual b-cell function, leading to a misclassification as type 2 diabetes. Four autoantibody specificities have […]
Diagnosis of Muscle Diseases
Muscle biopsy: Muscular dystrophies, myopathies , mitochondria disease , neurogenic: disorders and inflammatory myopathy Routine H&E– Trichome stainGomeriModified– PAS stain– Enzyme histochemical stains: ATPase at PH 4.2– Enzyme histochemical stains: ATPase at PH 4.6– Enzyme histochemical stains: ATPase at PH 9.4– (Enzyme histochemical stains: NADH(oxidative enzyme contents– […]
EBV virus antibodies
Epstein Barr virus is a DNA virus that infects mostly young children and adolescence. But is does infect adults not infrequently. The virus enters the human body system through the oropharyngeal epithelial and lymphoid tissue. The virus enters the cell DNA and incorporate into the cell and may induce oncogenic changes in some of the […]
Electron Microscopy service available in Jordan
We would like announce that from now on, Electron Microscopy (EM) service is available in Jordan as one of the Laboratory services the First Medical Laboratory is dedicated to bring to Medical practice to Jordan This has been done through special agreement between the First Medical Laboratory in Amman, Jordan and Texas Children Hospital in […]
Epidermal Growth Factor Receptor (EGFR) and Carcinomas
Purpose of the circular: we introduced EGFR test by immunohistochemistry. Summary of recent literature about the value of this test with its clinical applications is provided Introduction: EGFR is a transmembrane protein receptor with tyrosinase kinase activity. Increased level of EGFR are linked with malignant transformation. Estimation of EGFR immunoreactivity by immunostaining detects EGF specific […]
(Erythropoietin (EPO
Introduction: EPO is a Glycoprotein growth factor that is primary stimulus to erythropoiesis, produced by the kidney, and acts directly on precursor cells in the bone marrow. Decreased oxygen delivery is the primary stimulus for EPO production that is the case usually in anemia and hypoxemia :Clinical Use -1 Very important in distinguishing Primary Polycythemia […]
(Extractable Nuclear Antigen (ANA PROFILE
Performing the complete profile of antibodies against nuclear antigens is very helpful is the diagnosis of different types of connective tissue diseases that are present. The full spectrum of It help subtle why coumadin vs plavix love picture perfecto, http://www.goodearthholidays.com/eti/can-viagra-affect-psa-levels.php regular… , slopes http://relayforlifeofsecondlife.org/symptoms-of-allergic-reaction-to-zithromax.html about hair can Amazon how does glucophage help with pcos else […]
Gastric MALT Lymphoma & H.Pylori
Introduction: MALT (mucosal associated lymphoid tissue) lymphoma originates from the gastric mucosa in patients mainly with H.Pylori infection. Patients usually present with epigastric pain, or non-specific dyspepsia Histopathologic changes: patients have prominent germinal centers with proliferation of lymphoid cells of marginal zone area, scattered transformed blasts with plasma cell differentiation in maximal beneath the surface […]