Genetic Testing for Hemochromatosis
Hereditary Hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism. The frequency of the gene carriers among Northern European descent is estimated to be 1 in 10, resulting in up to 1: 200 homozygous subjects being predisposed to develop the disease HH is characterized by progressive accumulation of iron in various organs (liver, […]
Herpes Simplex Type I & Type II Testing by their Specific Glycoproteins
Both HSV types (type I&II) tests have cross reactivity in most of the routinely used test because the genetic material in both types are similar in over 85% of their contents. The discovery of glycoproteins on both HSV�s viruses gave us a lead in diagnosing them with very high sensitivity and specificity. Glycoproteins are found […]
Herpes Simplex Virus and Vulva Ulcers
Herpes simplex ulceration in the vulva can mimic other clinical condition of dermatitis. Exact diagnosis of herpes etiology has definite and different treatment compared to other types of vulvar ulceration and dermatitis. Histology alone only can till herpetic origin if typical nuclear inclusions seen. With immunohistochemistry to herpes simplex virus, we can diagnose up to […]
Human papilloma virus screening and genotyping By PCR
In our effort to bring the best of laboratory medicine in clinical practice to Jordan, We are glad to announce that identification of Human papilloma virus (HPV) genotyping by PCR is available now at our lab for most common 20 genotypes and include the followings (6,11,34,40,42,43,44,16,18,31,35,39,45,51,52,56,58,59,66,68) Human papilloma virus is double stranded DNA virus that […]
Immunophenotyping of small B-cell lymphomas group
We introduce several new tests in ” small lymphoma cell type group” that help in their differential. The lymphomas that may morphologically closely mimic each other, however treatment and prognosis may be quite different Small lymphocytic lymphoma- Mantle cell lymphoma- Follicular center lymphoma- Marginal zone lymphoma- Lymphoblasmacytoid lymphoma- Chronic lymphocytic leukemia/small lymphocytic lymphoma: diffuse infiltrate […]
Important Serological tests for the diagnosis of Crohn’s Disease and Ulcerative Colitis
With new development in immunology, medical scientists discovered new tests fairly specific for Crohn’s disease and / or ulcerative colitis. These tests can also differentiate between Crohn’s disease and ulcerative colitis Antibodies against Saccharomyces cervisiae: They are frequently found in serum of patients with Crohn’s disease. IgA level, specific marker for Crohn’s disease, detectable in […]
Important Tests in Dermatology
We, at the First Medical Laboratory, provide you with several important tests for dermatology diagnosis -1 Immunoflourescence test on the skin biopsy (IgG, IgA, IgM, C3, C4) : This test is important in cases of Pemphigus (intercellular IgG pattern), Pemphigoid (linearly deposited C3 and IgG along epidermal basement membrane) , Dermatitis herpetiformis (linear IgG along […]
Inhibin
A BETTER MEASUREMENT OF OVARIAN FUNCTION THAN FSH Inhibin is a hormone that is produced from granulosa cells of the ovary. It acts by inhibiting secretion of FSH. Measurement of Inhibin has been found recently to have a superior indication of the ovarian status than measurement of FSH Measurement of inhibin in the 3rd day […]
Kidney Transplant Rejection, C4d type
This is a newly described form of kidney transplant acute rejection in 1999, which is not uncommon. It affects about one third of all transplanted kidneys in the first 3 months post transplant. This form of rejection affects the microvascular peritubular capillary area. It is a form of acute antibody mediated rejection (humoral type). However, […]
Low molecular weight heparin and monitoring by anti-factor Xa
Low molecular weight heparin (LMWH) has many advantages over usual heparin. It has more predictable response rate with low side effect (like osteoporosis and thromboc ytopenia). LMWH is used as anti-coagulant in venous thromboembolic disease, in antiphospholipid syndrome , in repeated abortion in pregnancy and experimentally in some cancer treatment as an important �Tissue Factor […]