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We introduce several new tests in ” small lymphoma cell type group” that help in their differential. The lymphomas that may morphologically closely mimic each other, however treatment and prognosis may be quite different

 Small lymphocytic lymphoma-
Mantle cell lymphoma-
Follicular center lymphoma-
Marginal zone lymphoma-
Lymphoblasmacytoid lymphoma-

Chronic lymphocytic leukemia/small lymphocytic lymphoma: diffuse infiltrate of small round lymphocytes, with few paraimmunoblasts. The cells are

-CD20+, CD 5+, CD 10 -, Cyclin D1

Mantle cell lymphoma: composed of monotonous proliferation of small lymphocytes with slightly irregular nuclear contour. Scattered epitheliod histiocytes is useful feature. Immunohistochemistry shows that these cells are

+CD20 +, CD5 +, CD 10 -, Cyclin D1

Follicular center lymphoma: mixture of centocytes, and centroblasts in a follicular pattern. . Immunohistochemistry shows that these cells are

-CD20+, CD 5-, CD 10 +, Cyclin D1

Marginal zone lymphoma (includes MALT type and Splenic lymphoma with villous lymphocytes). The cells are of marginal zone type (centrocytes like). Monotypic plasma cells a helpful hint. Immunohistochemistry shows that these cells are

-CD20+, CD 5 -/+, CD10 -/+, Cyclin D1

Lymphoblasmacytoid lymphoma: It is associated with Waldestrom’s macroglobulinemia. Diffuse proliferation of round lymphocytes with cells with plasmacytoid of plasmacytic features. Immunohistochemistry shows that these cells are

-CD20+, CD 5 -, CD 10 -, Cyclin D1

All the above tests are performed now in the First Medical Laboratory

 

We , in the First Medical Laboratory, are dedicated to bring the best of laboratory medicine in clinical practice to Jordan

Please contact for any further inquires

.Dr. Hussam Abu- Farsakh, M.D

American boards of Anatomic, Clinical Pathology and Cytopathology