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In our effort to bring the best of laboratory medicine in clinical practice to Jordan, We are glad to announce that identification of Human papilloma virus (HPV) genotyping by PCR is available now at our lab for most common 20 genotypes and include the followings

(6,11,34,40,42,43,44,16,18,31,35,39,45,51,52,56,58,59,66,68)

Human papilloma virus is double stranded DNA virus that is incorporated with DNA of the nuclei of the basal layer of the keratinocytes of the exocervix and in the vulvar area.. The virus has the capability of transforming cells into mucosal malignancies

This virus is associated with dysplasia of the cervix (intraepithelial Neoplasia) and squamous cell carcinoma of the cervix

:Different genotypes have different potentials for malignancies

The genotypes that are associated with carcinomas are 16,18 (strong association); genotypes 31, 33,35,39,45,51,52,56 (moderate association); genotypes 6,11,42,43,44 (weak association ). Cervical squamous dysplasia (intraepithelial Neoplasia) is associated with genotypes 16,18,31,33,35,39,42,43,44,45,51,52,56. Genital warts (condyloma accuminata) are associated with 6 and 11. Flat condylomata is associated with genotypes 6,11,16,18,31

Material required: The test can be done on blood or online casino on cervical swabs

Treatment of HPV infections depends largely on the site of the infections and on the genotype of the virus. HPV genotypes with strong or moderate association, require more aggressive therapy with closer follow up

Conclusion: genotyping of Human papilloma virus has very important role in clinical practice and decision making. It is strongly advised that any patient with Human papilloma virus changes in the pap smear, has to be examined for genotyping of HPV. This first will confirm the HPV presence and second will determine the mode of therapy to be taken

 

Please call us for any further information

.Dr. Hussam Abu-Farsakh, M.D

American boards of Anatomic, clinical pathology & Cytopathology