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%Normal range: 20-125

Comment: Ceruloplasmin, a liver product, is the copper containing protein of plasma. About 70%to 90% of copper in plasma is bound to this protein. It is decreased in Wilson disease (hepatolenticular degeneration), menkes syndrome, and nutritional deficiency. It is an acute phase reactant and as such is increased in infections, malignancy, in pregnancy with estrogens, and in trauma. Wilson disease (WD) is an autosomal recessive abnormality of copper metabolism. Diagnosis of WD can sometimes be made on the basis of hypoceruloplasminemia, hypocupremia, and hypercupruria, with abnormalities in liver-related tests. Liver biopsy is often necessary for diagnosis of WD

Sample: serum