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Normal range:80-120 % of normal plasma activity

Comment: Von Willebrand’s disease is an autosomal domiminantly transmitted factor VIII defect. It is a coagulation disorder that results in varying degrees of bleeding abnormalities. The von Willebrand factor has two important functions in hemostasis: It mediates platelet adhesion

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at the site of injury and transports and stabilizes Factor VIII in the stabilizes Factor VIII in the circulation. Consequently, the deficiency of Factor VIII in blood, the usage of these tests is mainly to differentiate between Hemophilia A and von Willebrand’s disease

Sample:Citrated plasma, fresh