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(HLA (A, B, C-

Normal range: Negative

Comment: Histocompatibility (HLA typing) antigens are glycopeptides present on the cell surface of most tissues in the body, essential for immune recognition. Leukocytes of each individual bear a unique HLA antigen code may allow prediction of which immunologic diseases each individual is susceptible to. HLA B-27 for example is a risk prediction marker for ankylosing spondylitis and essential in donor selection of organ transplant. HLA genes site is known to have multiple alleles, they are all coexpressed. The serologically detected antigens can be classified into 4 main groups: HLA-A, HLA-B, HLA-C, HLA-D R, P&Q

Sample: Heparin, whole blood

 

HLA B27-

Normal range: Negative

Comment: Although the tissue type antigen HLA B 27 is present in 4-8%5 of the normal population, it is present in 88-96% of patients with ankylosing spondylitis. Can be detected serologically or by flowcytometry

Sample: Heparin, whole blood

 

HLA B5-

Normal range: Negative

Comment: There is close association between its presence and Behcets disease

Sample: Heparin, whole blood

 

HLA DR-

Normal range: Negative

Comment: HLA-DR play a major role in antigen presentation and graft rejection. Typing of HLA-DR antigens can be determined seroloically or more specifically at the genetic level using the PCR technique

Sample: EDTA, whole blood