Introduction: MRP is a surface glycoprotein that is expressed in the cell surface of many tumor cells and contributes to the tumor resistance, by moving chemotherapy (efflux) out of the cells
Clinical use: In acute leukemias, that are secondary (to Myelodysplasia or to Alkylating agents) or that occur in the elderly, the chance of expressing this gene is over 75%, while in de nevo cases occurs in 30% in younger patients
It is proved now beyond doubt that the expression of this gene is highly predictive of lower complete remission rate and more resistant disease. In addition, Cases with MRP have trilineage dysplasia
It is considered now a subentity based on the old FAB leukemia classification due to their poor response
Summary: Recognition of this subset of MRP positive cases is essentially important in acute leukemias that occur typically in older individual and in 30% of younger AML cases. Its recognition is important for treatment strategies and prognosis
We, in the First Medical Lab, have introduced this test that can be performed in bone marrow smears or in trephine biopsy. We are doing this in our effort to bring the best of laboratory medicine to clinical practice in Jordan
Please do not hesitate to contact us for further details
Dr. Hussam Abu-Farsakh
American boards of Anatomic, Clinical Pathology and Cytopathology