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Immunohistochemistry for this marker has emerged as a valuable diagnostic aid in the diagnosis of CIN (cervical dysplasia). It has proven benefit in distinguishing high-grade cervical dysplasia from

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its benign mimics such as cervical atrophy, immature squamous metaplasia, reactive inflammatory lesions, and radiation induced changes. Overexpression of p16 is a useful biomarker of HPV related carcinogenesis. P16, when it is positive in low grade CIN, can predict its progression to higher CIN grade

Sample: unstained slide from cervical swab