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Normal range: TPSA: up to 4.0 ng/mL

Comment: Prostatic specific antigen, human kallikrein-3 (hK3), is a seine protease that is produced almost exclusively by epithelial cells of prostatic tissue. It is present at high concentrations in seminal fluid and functions in the liquefaction of seminal coagulum. Preoperative PSA serum levels correlate (but imperfectly) with extent of disease in patients with prostate cancer. PSA density is obtained by division of serum PSA result by prostatic weight utilizing transrectal ultrasound (TRUS) volumetric measurements: PSA density = [PSA] / total prostate volume; units = ng/ml/ cc

Sample: serum