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Normal range: 1.8-3.9 mg/L

Comment: This Vitamin K-dependent protein is an important inhibitor of inappropriate thrombin formation. Deficiency, either congenital or acquired, predisposes to arterial or venous thrombosis, particularly in high-risk clinical situations such as pregnancy or following major surgery. Skin necrosis may occur following the first few days of Warfarin therapy in protein C deficiency unless heparin is used during this phase. Oral anticoagulant therapy depresses levels of this protein; there should be a 4-week’s cessation of Warfarin before the test

Sample: Citrated plasma