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Therapeutic range: 4-12 ng/mL

Comment: Sirolimus is used for the prophylaxis of organ rejection in kidney transplant patients, and is recommended

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in combination with cyclosporin and corticosteroids. Therapeutic monitoring has been shown to be helpful in cases of patients with hepatic impairment, pediatric patients and patients receiving concurrent doses of drug known to interact with Sirolimus. The therapeutic range may vary with other transplant organs, when used in combination with drugs other than cyclosporine (or sirolimus alone), with approach of the transplant center, and with other factors

Sample: EDTA whole blood