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 Autoimmune hepatitis is a treatable liver disease; this makes its diagnosis of paramount importance

:Three types of Autoimmune Hepatitis are recognized

Type I: Positive Anti-smooth muscle antibody (ASMA) and ANA. Represents the most common type of auto-immune hepatitis. 38% of the patients may have concomitant immunologic diseases: autoimmune thyroiditis, Grave’s disease, Synovitis, or ulcerative colitis. 40% may present as acute hepatitis

Type II: positive for Liver/Kidney microsomal antibodies (Anti-LKM1) occurs usually in children. But can occur in 20% of adults with autoimmune hepatitis. Associated with antibodies against thyroid, parietal cells and islet cells of Langerhan’s

Type 3: positive for soluble liver Antigen (SLA), has similar clinical presentation as type I (except that it is negative for ASMA and ANA). Most of the patients are women (91%), with mean age of 37 years

Primary biliary cirrhosis: Anti-mitochondria M2 is a specific marker for primary biliary cirrhosis

It is strongly recommended to perform the following auto antibodeis for primary liver disease suspected of autoimmune origin: ANA, ASMA, Anti-LKM1, Anti-SLA, and Anti-M2

Test Price for the three antibodies: Anti-LKM1, Anti-SLA, and Anti-M2: 50 J.D

We, at the First Medical Laboratories, are dedicated to bring the best of Laboratory medicine in clinical practice to Jordan

Please call us for any further details

.Dr. Hussam Abu- Farsakh, M.D

American boards of Anatomic, Clinical Pathology and Cytopathology

 

Circular: is a periodic circular that distributed to clinician informing them about new and important tests available at First Medical Laboratory. All information listed are supported by recent literature