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Normal range: GH and IGF-1 are elevated   during normal puberty. Values vary with age, sex, and among laboratories. Adult: 130-450 ng/mL. Range is lower in males. It is increased with puberty and pregnancy

Comment: The insulin – like factors (IGFs, also called somatomedins are peptides which are related to the concentration of growth hormone (GH). Two IGFs are of medical interest: IGF-1 (somatomedin C) and IgF-2. The formeris used in evaluation of growth disorders, and is generally a better test than is assay for basal – and glucose –suppressed growth hormone. IGF-1 circulates in the body, mostly bound to insulin – like growth factor binding proteins (IGFBPs) mainly IGFBPs

(Increased: when GH increased (acromegaly

Decreased: dwarfism

Sample: Serum, fasting freeze immediately