Author Archives: د.حسام أبو فرسخ

(Influenza A and B virus (IgG/M

Normal range: Negative

Comment: Influenza type A and B viruses belong to the family Orthomyxoviridae. Infection with influenza is usually an acute, self – limiting, febrile illness that occurs in outbreaks seasonally (winter months in temperate climates). At time pandemics of influenza have occurred due

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to the emergence of a new virus to which the world wide population lacks immunity

Sample: serum

Infection Profiles

-1

(Gastrointestinal infectious profile (IgG/IgM

                      See gastrointestinal infection profile

-2

(Myocarditis Profile (IgG/IgM

                    See Myocarditis profile

-3

(Respiratory Tract infection Profile (IgG/IgM

                      See Respiratory Tract Infection

(Infectious Mononucleosis (Monospot

Normal range: Negative

Comment:Infectious mononucleosis (IM) is a self –limiting disease caused by the Epstein-Barr virus (EBV), characterized clinically by fever, cervical lymphadenitis, tonsillopharyngitis, and not infrequently, hepatosplenomegaly. Petechiae maybe found on the palate. About 5% of patients are jaundiced

Sample: serum

India ink

Normal range: No Cryptococcus identified

Comment: Establish a diagnosis of cryptococcal meningitis; orgasms maybe identified in cytologic preparations with papanicolaou stain as well as with India ink

Sample: Cerebrospinal fluid

Immunofixation Electrophoresis, serum or urine

Normal range: No applicable; each study should be accompanied by an interpretive report

Comment: Evaluate and characterize clinical conditions (eg, plasmacytic, in particular multiple myeloma, lymphocytic, protein infiltrative, or other) that maybe associated with monoclonal gammopathy (M-protein) detected initially on protein electrophoretic study of serum, urine, cerebrospinal fluid, or other body fluids. Detect, quantitate, and analyze abnormal specific (but non-M-protein) serum protein populations. Can be used for detection of leakage of CSF into nose or ear, in which a beta-2 transferrin band maybe detected by use of antiserum against human transferrin. There maybe problems with sensitivity (a negative result cannot exclude CSF leakage). Congenital atransferrinemia is rare occurrence; a serum control should be used

Sample: serum

IgM

Normal range: 40-250 mg/dl

Comment: Gamma globulin fraction of plasma proteins. It protects blood stream. It is the primary response to antigen. It lyses bacteria. Complement activated

Sample: serum

IgG

Normal range: 710-1520 mg/dl

Comment: Gamma globulin fraction of plasma proteins. Protects extra vascular tissue spaces. Secondary response to antigen neutralises toxins. Complement activated

Sample: Negative

IgE

:Normal range

(Adult : 24-432 mg/L (10-180 IU/mL

(Child  : 4.8-86.4 mg/L (2.0-36.0 IU/mL

Comment: Very high IgE levels maybe helpful diagnostically. Atopic disease is likely if the total IgE level ³ 375 IU/mL. Extreme elevations of 800-25.000IU/mL are found in asthma associated with sever atopic dermatitis, allergic bronchopulmonary aspergillosis, parasitic infections, IgE myeloma, and Buckley syndrome

Sample: Serum

IgD

Normal range: 14-222 IU/mL

Comment: Investigation of monoclonal gammapathy for diagnosis of IgD myeloma

Sample: serum

IgA

Normal range: 10-490 mg/dL

Comment: IgA deficiency is associated with mild recurrent respiratory tract infection and with intestinal disease. Raised in multiple myeloma and

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chronic inflammatory disorders

Sample: Serum