Not uncommonly we encounter cases of prostate biopsy where we see small focus of glands that we can not call benign and at the same time we can not be sure that it is malignant. We the new advances in Immunohistochemistry , now we can examine the basal layer in the prostate glands. This basal… Read More: Prostate Biopsy With Small Atypical Focus Of Glands, What Is… »
Carcinoma in Situ (CIS) of the urinary bladder can be confused by the histopathologist for reactive atypia in some cases and vise versa. Since making this diagnosis is of paramount importance, unequivocal diagnosis is not helpful. The recent advances made in Immunohistochmistry can help in solving this problem. An immnunostaining panel consisting of cytokeratin 20… Read More: Role of Immunohistochmistry in Carcinoma in Situ of the urinary… »
Inhibin is a glycoprotein hormone that is produced from Sertoli cells (in the seminiferous tubules) of the testis. It has a positive action on the spermatogenesis and it inhibits the secretion of FSH from the pituitary Inhibin rarely circulates freely in the blood. It combines with alpha2-macroglobulin protein. The administration of FSH increases the secretion… Read More: Role of Inhibin in Male Infertility »
Autoimmune hepatitis is a treatable liver disease; this makes its diagnosis of paramount importance :Three types of Autoimmune Hepatitis are recognized Type I: Positive Anti-smooth muscle antibody (ASMA) and ANA. Represents the most common type of auto-immune hepatitis. 38% of the patients may have concomitant immunologic diseases: autoimmune thyroiditis, Grave’s disease, Synovitis, or ulcerative colitis.… Read More: Soluble liver Antigen (SLA), LKM-1, Anti-mitochondrial M2 antibody and Auto-immune… »
In our lab we do several stains for diagnosing diverse liver disease. Of the new stains that we have now in our lab and essential in diagnosing different liver diseases Copper Stain :is important in cases of suspected Wilson disease, biliary cirrhosis, Indian childhood cirrhosis – Lead stain: important in suspected lead intoxication – Alpha1-anti-trypsin… Read More: Special Stains in the Diagnosis of Liver Diseases »
Diffuse large B cell lymphoma (DLBCL) is not one disease, but it is at least 3 different diseases. DLBCL can be of different cell origin. The cell origin determines the prognosis in such lymphomas. The cell of origin can be of germinal center B-cell (GCB ) or from Activated B-cells (ABC), or from an in… Read More: SUBTYPING CD20 POSITIVE LARGE B-CELL LYMPHOMA »
ANCA (Anti-Neutrophilic Cytoplasmic Antigen) is very important test for vasculitis and inflammatory bowel diseases and certain hepatic lesions. It is important in the differential diagnosis of “Lung diseases” , “hematuria and/or proteinuria”, “abdominal pain and bloody diarrhea” and in “Cholestatic liver diseases” (ANCA has 2 different patterns: Perinuclear ANCA (P-ANCA) and Cytoplasmic ANCA (C-ANCA C-ANCA… Read More: The Significance of Different Patterns of ANCA »
Tissue Transglutaminse (TG) is an enzyme that is involved in protein synthesis and wound healing. It is present in the gut in abundant amount to build the villi and endomysium connective tissue from the continuous damage. This enzyme uses gliadin ( a component of gluten) as Better black manliness danger of using prednisone me nice… Read More: Tissue Transglutaminse IgA Antibody, A Diagnostic Test For Celiac Disease »
We would like to inform you that we have, in the First Medical Laboratories, several tumor markers that can be of great help in the diagnosis of different tumors. Diagnosis and classification of tumors now become much easier in Jordan with these new tests Calcitonin: essential for the diagnosis of medullary carcinoma of the thyroid… Read More: (Tumor markers on tissue sections (Paraffin blocks »
P53 is a tumor suppressor gene, that is present in all normal cells on Chromosome 17. It is very important molecule in the control of cancer formation in the cancer cycle. Mutation in P53 results in the loss of P53 function and progression of cells into cancer cells. This form of P53 is called “mutant”… Read More: Value of P53 in Gastrointestinal Disease »