Normal range: Negative Comment: Aid the differential diagnosis of diffuse scleroderma (Progressive systemic sclerosis). The antibody is found in up to a quarter of individuals who have idiopathic Raynaud phenomenon. It is also seen in inflammatory myositis Sample: serum
Normal range: Negative Comment: Antibodies against Yo (PCA-1) particularly indicate breast and ovarian carcinomas. They are also associated with paraneoplastic neurological syndrome PNS Sample: serum
Normal range: Negative Comment: This assay may provide support in the differential diagnosis between Grave’s disease and toxic nodular goiter, and may also be used to monitor the role of anti thyroid drugs. Despite the importance of the thyrotropin receptor antibody (TRAB) in the pathogenesis of Grave’s disease, the test is not often used in… Read More »
Normal range: Negative < 35 IU/mL Comment: Thyroperoxidase (TPO) is the major antigen in antibody-dependent cell-mediated cytotoxicity in thyroid disease. Chronic autoimmune thyroiditis maybe sub clinical or may present with hypothyroidism and / or goiter. Thyroid antibodies include thyroglobulin and thyroperoxidase (Microsomal) antibodies. Measurement of TPO –Ab is more sensitive test for diagnosis of autoimmune… Read More »
Normal range: Negative Comment: Hashimoto’s thyroditis. Frequency of positive results in thyroid autoimmune disease is higher than in the thyroglobulin antibodies test, especially in people less than 20 yrs of age Sample: Serum
Normal range: Negative Comment: Frequently done in combination with Thyroid Microsomal antibodies. Positive in some cases of Hashimoto’s thyroiditis, some cases of Graves’ disease and at lower titers in some other thyroid diseases, also it is positive in thyroid carcinoma, idiopathic myxedema and pernicious anemia Sample: serum
Normal range: 80-120 % of Normal Plasma Activity Comment: Decreased levels found in congenital anti thrombin III deficiency, liver disease and disseminated intra vascular coagulation (DIC). Patients with values below 0.6 IU/ml are especially at risk of thrombosis. Deficiency can also result in resistance to heparin therapy, necessitating higher doses of the latter. Levels are… Read More »
Normal range: Negative Comment: Infertility in males Sample: serum
Normal range: Negative Comment: Used in the serologic assessment of certain muscular diseases. Titers with values 1:80 are suggestive of myasthenia; striated muscle antibody can also be found in rheumatic fever, myocardial infraction, and a variety of post-cardiotomy states Sample: serum
Normal range: Titer < 200 IU/M Comment: A high or rising titer is indicative of streptococcal infection. This is especially useful diagnosis and follow- up of rheumatic fever and acute glomerulonephritis Sample: Serum