Author Archives: د.حسام أبو فرسخ

(Anti SS-A (Ro

Normal range: Negative

Comment: SS-A (Ro) and SS-B (La) are useful in diagnosis of Sjogren syndrome (especially with Vasculitis) and some forms of lupus; maybe present in anti phospholipid antibody syndrome

Sample: serum

Anti Sperm Antibody

Normal range: Negative

Comment: Recommended in the assessment of infertility. Antibodies may be detected in serum of both sexes, seminal fluid and cervical mucus

Sample: serum

(Anti Smooth Muscle Antibody (ASMA

Normal range: Negative

Comment: This autoimmune antibody is detectable in chronic active hepatitis, viral hepatitis, cryptogenic cirrhosis, primary biliary cirrhosis, 30% of patients with a positive LE preparation but with a negative anti-DNA test

Sample: serum

Anti Smith (Sm) Antibodies

Normal range: Negative

Comment: Smith antibody (Sm) is very specific for systemic lupus erythematous (SLE cases. The presence of antibodies to Smith is often associated with renal disease

Sample: Serum

Anti Sm/RNP

Normal range: Negative

Comment: Confirm the diagnosis of systemic lupus erythematous (SLE) or mixed connective tissue disease (MCTD). In the presence of possible diseases similar to SLE, with ANA positivity, anti –ds-DNA and anti-Sm may be helpful

Sample: Serum

Anti Scleroderma (SCL-70) Antibodies

Normal range: Negative

Comment: Scleroderma (Scl-70) antibody is seen in 20-60% of patients with scleroderma and is considered diagnostic and specific for scleroderma if it is the only ENA antibody present. Scl-70 is also seen in approximately 25% of progressive systemic sclerosis PSS

Sample: serum

Anti Saccharomyces Cerevisiae Antibodies

Normal range: Negative

Comment:They are frequently found in serum of patients with Crohn’s disease. IgA level, specific marker for Crohn’s disease, detectable in 63% of the cases (compared to 4% of ulcerative colitis patients, and 2% in normal population), Combined IgA and IgG detect 73% of the cases

Sample: serum

Anti RNP

Normal range: Negative

Comment: Auto-immune Myositis Mixed connective tissue disease associated with positivity of Anti-RNP

Sample: serum