Normal range: Adult: <20 % of total solids
Comment: Fecal fat is measured to aid diagnosis of conditions causing poor absorption of dietary fat resulting in steatorrhea. The value of this test is that the amount of dietary fat intake is known and used in evaluation of the results
Sample: Stool
Normal range: 15-50%
Comment: Factor XI deficiency is inherited in an autosomal recessive manner. The associated prolongation of the APT is not always associated with a bleeding disorder. When present, bleeding is usually mild, with a delayed bleeding pattern. Factor
XI deficiency is seen most commonly in a Sephardim Jewish population
Sample: Citrated plasma, fresh
For monitoring of low molecular weight heparin
(Sample: citrated plasma, under ice (frozen
Normal range:80-120 % of normal plasma activity
Comment: Von Willebrand’s disease is an autosomal domiminantly transmitted factor VIII defect. It is a coagulation disorder that results in varying degrees of bleeding abnormalities. The von Willebrand factor has two important functions in hemostasis: It mediates platelet adhesion
at the site of injury and transports and stabilizes Factor VIII in the stabilizes Factor VIII in the circulation. Consequently, the deficiency of Factor VIII in blood, the usage of these tests is mainly to differentiate between Hemophilia A and von Willebrand’s disease
Sample:Citrated plasma, fresh
Normal range: 70-130%
Comment: Factor VII deficiency is inherited as an autosomal recessive bleeding disorder. It can be diagnosed fairly easily as it is the only factor deficiency that will give a prolongation of a single result in the clotting screen, i.e. the prothrombin time. Factor VII deficiency also occurs in the early stage also occurs in the early stages of Warfarin therapy and is one of the factors affected by oral anticoagulants. Liver disease will also affect the levels of Factor VII and therefore the prothrombin time
Sample:Citrated plasma, fresh
Normal range: Negative
Comment: Factor V Leiden is the genetic mutation responsible increased tendency for thrombosis. The most significant inherited disorder in thrombophilia
Sample: 5 ml whole blood EDTA tube Don’t Separate
Normal range: 70-120%
Comment: Factor V (F5) is inherited in an autosomal recessive manner. Deficiency is extremely rare. The coagulation screen in an affected individual is the same as in Factor X deficiency, i.e. the PTT and the APTT are both prolonged
Sample: Citrated plasma, fresh
Normal range: 50 –80%
Comment: Treatment of bleeding caused by multiple labile and stable coagulation factor deficiencies (e.g.: liver disease, DIC); with massive transfusion and abnormal coagulation assays, in sever warfarin effect, with cardiac by pass surgery and as replacement medium in plasma exchange for thrombotic thrombocytopenic purpura
Sample: Citrated plasma, fresh
Normal range: Negative
Comment: The factor II prothrombin G20210A mutation is a common genetic risk factor for thrombosis and is associated with elevated prothrombin levels. Although homozygosity is rare, inheritance of two 20210A alleles would increase the risk for developing thrombosis. If a patient heterozygous for both the prothrombin G20210A and the factor V Leiden mutation, the combined heterozygosity leads to an earlier onset of thrombosis and tends to be more sever than single–gene heterozygotes
Sample: EDTA whole blood
Normal range: 10%-40%
Comment: To determine the etiology of a prolonged PT or PTT, and to identify specific factor deficiencies or inhibitors. Factor II, V, VII, and X are performed to evaluate a prolonged PT with normal PTT
Sample: Citrated plasma, fresh