Carcinoma in Situ (CIS) of the urinary bladder can be confused by the histopathologist for reactive atypia in some cases and vise versa. Since making this diagnosis is of paramount importance, unequivocal diagnosis is not helpful. The recent advances made in Immunohistochmistry can help in solving this problem. An immnunostaining panel consisting of cytokeratin 20… Read More »
Inhibin is a glycoprotein hormone that is produced from Sertoli cells (in the seminiferous tubules) of the testis. It has a positive action on the spermatogenesis and it inhibits the secretion of FSH from the pituitary Inhibin rarely circulates freely in the blood. It combines with alpha2-macroglobulin protein. The administration of FSH increases the secretion… Read More »
Autoimmune hepatitis is a treatable liver disease; this makes its diagnosis of paramount importance :Three types of Autoimmune Hepatitis are recognized Type I: Positive Anti-smooth muscle antibody (ASMA) and ANA. Represents the most common type of auto-immune hepatitis. 38% of the patients may have concomitant immunologic diseases: autoimmune thyroiditis, Grave’s disease, Synovitis, or ulcerative colitis.… Read More »
In our lab we do several stains for diagnosing diverse liver disease. Of the new stains that we have now in our lab and essential in diagnosing different liver diseases Copper Stain :is important in cases of suspected Wilson disease, biliary cirrhosis, Indian childhood cirrhosis – Lead stain: important in suspected lead intoxication – Alpha1-anti-trypsin… Read More »
Diffuse large B cell lymphoma (DLBCL) is not one disease, but it is at least 3 different diseases. DLBCL can be of different cell origin. The cell origin determines the prognosis in such lymphomas. The cell of origin can be of germinal center B-cell (GCB ) or from Activated B-cells (ABC), or from an in… Read More »
ANCA (Anti-Neutrophilic Cytoplasmic Antigen) is very important test for vasculitis and inflammatory bowel diseases and certain hepatic lesions. It is important in the differential diagnosis of “Lung diseases” , “hematuria and/or proteinuria”, “abdominal pain and bloody diarrhea” and in “Cholestatic liver diseases” (ANCA has 2 different patterns: Perinuclear ANCA (P-ANCA) and Cytoplasmic ANCA (C-ANCA C-ANCA… Read More »
Tissue Transglutaminse (TG) is an enzyme that is involved in protein synthesis and wound healing. It is present in the gut in abundant amount to build the villi and endomysium connective tissue from the continuous damage. This enzyme uses gliadin ( a component of gluten) as Better black manliness danger of using prednisone me nice… Read More »
We would like to inform you that we have, in the First Medical Laboratories, several tumor markers that can be of great help in the diagnosis of different tumors. Diagnosis and classification of tumors now become much easier in Jordan with these new tests Calcitonin: essential for the diagnosis of medullary carcinoma of the thyroid… Read More »
P53 is a tumor suppressor gene, that is present in all normal cells on Chromosome 17. It is very important molecule in the control of cancer formation in the cancer cycle. Mutation in P53 results in the loss of P53 function and progression of cells into cancer cells. This form of P53 is called “mutant”… Read More »
Venous thrombosis is among the three most common cardiovascular diseases affecting about 1:1000 individual each year. Thrombosis risk is determined by genetic risks, in addition to other factors surgery, age, pregnancy, contraceptives We would like to announce that we have an updated profile of causes of thrombosis Factor V leiden (by PCR): is most common… Read More »